Activities and Projects

Open:

Projects in close collaboration with other committees in the field of early toxicity:

• Supportive care in leukaemia treatment
• Toxicity issues in NHL
• Middle and late term toxicity in ALL
• Prevention, Diagnosis & Management of Thrombosis & Bleeding in Children with Acute Lymphoblastic Leukaemia: European Survey of Current Practice

Projects in the field of late toxicity inside I-BFM :

• Survey on your knowledge about your disease and later care

Projects in the field of late toxicity in collaboration with PanCare:

• PanCareLife
• Survivorship Passport

Completed

PanCareSurFup (1.2.2011-31.1.2017)

Selected Publications

Feijen EL, van der Pal HJ, van Dalen EC, Mulder RL, Bardi E, Kuehni C, Tissing WJ, Kremer LC. A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records. PLoS One.2014 Jul 9;9(7):e100432. doi: 10.1371/journal.pone.0100432. eCollection 2014.

Terenziani M¹, Spinelli M, Jankovic M, Bardi E, Hjorth L, Haupt R, Michel G, Byrne J; on behalf of the PanCare NetworkPediatr Blood Cancer.Practices of pediatric oncology and hematology providers regarding fertility issues: A European survey. Pediatr. Blood Cancer 2014 Jul 25. doi: 10.1002/pbc.25163.

Brown MC, Levitt GA, Frey E, Bárdi E, Haupt R, Hjorth L, Kremer L, Kuehni CE, Lettner C, Mulder RL, Michel G, Skinner R; on behalf of the PanCareSurFup Consortium The views of European clinicians on guidelines for long-term follow-up of childhood cancer survivors.Pediatr Blood Cancer. 2014 Nov 8. doi: 10.1002/pbc.25310.

Hjorth L, Haupt R, Skinner R, Grabow D, Byrne J, Karner S, Levitt G, Michel G, van der Pal H, Bárdi E, Beck JD, de Vathaire F, Essig S, Frey E, Garwicz S, Hawkins M, Jakab Z, Jankovic M, Kazanowska B, Kepak T, Kremer L, Lackner H, Sugden E, Terenziani M, Zaletel LZ ,Kaatsch P; PanCare Network. Survivorship after childhood cancer: PanCare: a European Network to promote optimal long-term care Eur J Cancer.2015 Jul;51(10):1203-11. doi: 10.1016/j.ejca.2015.04.002. Epub 2015 May

Mulder RL, van der Pal HJ, Levitt GA, Skinner R, Kremer LC, Brown MC, Bárdi E, Windsor R, Michel G, Frey E: Transition guidelines: An important step in the future care for childhood cancer survivors. A comprehensive definition as groundwork. Eur J Cancer. 2016 Feb;54:64-8. doi: 10.1016/j.ejca.2015.10.007. Epub 2015 Dec 28

Feijen EA, Font-Gonzalez A, van Dalen EC, van der Pal HJ, Reulen RC, Winter DL, Kuehni CE, Haupt R, Alessi D, Byrne J, Bardi E, Jakab Z, Grabow D, Garwicz S, Jankovic M, Levitt GA, Skinner R, Zadravec Zaletel L, Hjorth L, Tissing WJ, de Vathaire F, Hawkins MM, Kremer LC; PanCareSurFup consortiumLate Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup. PLoS One. 2016 Sep 19;11(9):e0162778. doi: 10.1371/journal.pone.0162778. eCollection 2016.

Lehrnbecher T, Robinson PD, Fisher BT, Castagnola E, Groll AH, Steinbach WJ, Zaoutis TE, Negeri ZF, Beyene J, Phillips B, Sung L. Galactomannan, Beta-D-Glucan and PCR-Based Assays for the Diagnosis of Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. Clinical Infectious Diseases 2016; in press.

Phillips RS, Bhuller K, Sung L, Ammann RA, Tissing WJ, Lehrnbecher T, Stewart LA; PICNICC Collaboration Risk stratification in febrile neutropenic episodes in adolescent/young adult patients with cancer. Eur J Cancer. 2016 64:101-6

Tramsen L, Salzmann-Manrique E, Bochennek K, Klingebiel T, Reinhardt D, Creutzig U, Sung L, Lehrnbecher T Lack of effectiveness of neutropenic diet and social restrictions as anti-infective measures in children with acute myeloid leukemia: an analysis of study AML-BFM 2004. J Clin Oncol 2016; 10;34(23):2776-83

Phillips RS, Sung L, Ammann RA, Riley RD, Castagnola E, Haeusler GM, Klaassen R, Tissing WJ, Lehrnbecher T, Chisholm J, Hakim H, Ranasinghe N, Paesmans M, Hann IM, Stewart LA Predicting microbiologically defined infection in febrile neutropenic episodes in children: global individual participant data multivariable meta-analysis. Br J Cancer 2016; 114:623-33

Robinson PD, Lehrnbecher T, Phillips R, Dupuis LL, Sung L Strategies for Empiric Management of Pediatric Fever and Neutropenia in Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: A Systematic Review of Randomized Trials. J Clin Oncol 2016; 10;34(17):2054-60.

Hassler A, Bochennek K, Gilfert J, Perner C, Schöning S, Creutzig U, Reinhardt D, Lehrnbecher T Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML-BFM 2004. Pediatr Blood Cancer 2016; 63:1070-4.

Bochennek K, Hassler A, Perner C, Gilfert J, Schöning S, Klingebiel T, Reinhardt D, Creutzig U, Lehrnbecher T Infectious complications in children with acute myeloid leukemia: decreased mortality in multicenter trial AML-BFM 2004. Blood Cancer J 2016; 15;6:e382.

Alexander S, Pole JD, Gibson P, Lee M, Hesser T, Chi SN, Dvorak CC, Fisher B, Hasle H, Kanerva J, Möricke A, Phillips B, Raetz E, Rodriguez-Galindo C, Samarasinghe S, Schmiegelow K, Tissing W, Lehrnbecher T, Sung L Classification of treatment-related mortality in children with cancer: a systematic assessment. Lancet Oncol 2015; 16: e604-e611

Lehrnbecher T Antifungal prophylaxis in pediatric patients undergoing therapy for cancer: drugs and dosing. Current Opinion Infect Dis 2015; 28: 523-531

Lehrnbecher T, Phillilps R, Alexander S, Alvaro F, Carlesse F, Fisher B, Hakim H, Santolaya M, Castagnola E, Davis BL, Dupuis LL, Gibson F, Groll AH, Gaur A, Gupta A, Kebudi R, Petrilli S, Steinbach WJ, Villarroel M, Zaoutis T, Sung L: Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem cell transplantation.  Journal of Clinical Oncology 2012: 30(35): 4427-38.  SRI

Sung L, Aplenc R, Alonzo TA, Gerbing RB, Lehrnbecher T, Gamis AS: Effectiveness of supportive care measures to reduce infections in pediatric AML: A report from the Children’s Oncology Group. Blood 2013: 121(18): 3573-7.

Chellapandian D, Lehrnbecher T, Phillips B, Fisher B, Zaoutis T, Steinbach W, Beyene J, Sung L: Broncho-alveolar lavage and lung biopsy in patients with cancer and hematopoietic stem cell transplantation recipients: a systematic review and meta-analysis. Journal of Clinical Oncology 2015: 33(5): 501-509.